متلازمة زولينجر–إليسون

Symptoms of Zollinger-Ellison Syndrome

• Persistent abdominal pain
• Recurrent peptic ulcers
• Diarrhea
• Acid reflux or heartburn
• Nausea and vomiting
• Weight loss
• Bleeding ulcers (in severe cases)

Overview 

Zollinger-Ellison Syndrome is a rare condition in which one or more tumors called gastrinomas form in the pancreas or duodenum. These tumors produce excessive amounts of the hormone gastrin, leading to increased stomach acid production.

This excess acid can cause severe and recurrent peptic ulcers, abdominal pain, and digestive issues. Early diagnosis and proper treatment are essential to prevent complications.

Types of Zollinger-Ellison Syndrome Disease

• Sporadic Zollinger-Ellison Syndrome: Occurs without inherited cause
• MEN1-Associated ZES: Linked to Multiple Endocrine Neoplasia Type 1

Causes of Zollinger-Ellison Syndrome

• Gastrin-secreting tumors (gastrinomas)
• Genetic mutations (especially MEN1 syndrome)
• Excess gastrin leading to high stomach acid

Complications of Zollinger-Ellison Syndrome

• Severe peptic ulcers
• Gastrointestinal bleeding
• Perforation of stomach or intestines
• Malabsorption
• Tumor spread (malignancy in some cases)

Risk Factors of Zollinger-Ellison Syndrome

• Family history of MEN1 syndrome
• Genetic predisposition
• Middle-aged adults (commonly affected)

Prevention of Zollinger-Ellison Syndrome

• Genetic counseling for high-risk individuals
• Early detection and monitoring
• Regular medical check-ups